I've been using the Evernote Notetaking application for about 3 months now and I absolutely love it! Evernote is more than a simple notetaking application because it allows you to create a note from anything...photo, web page, text note, pdf file, etc.
All of your notes are organized in notebooks and can be tagged in addition to being organized by notebook. I have tried other notetaking applications in the past but the reason I really use Evernote is because it is so easy for me to create notes from whatever my current location may be.
If I am on the go, I can create notes from my phone by sending photos, text notes, web links or screen shots directly from my phone to the Evernote notebook of my choice.
From my computer, I can use the webclipper icon to send any highlighted text or images to the notebook of my choice, the Clip to Evernote toolbar icon to send the current webpage, or I can simply open the desktop or web versions of the application to create a new note.
They give you 40mb of note space for free each month and you can get a lot more space for only $5 per month. There are also a ton of other great features (too many to describe when I am this exhausted from a full day of work.)
Go to www.evernote.com to check out Evernote for free!